◇発表者◇
　Yingxu Liu　　
　人間・社会領域
　博士研究教育院生3年
　医学系研究科　医科学専攻

◇学会名称◇
　Alzheimer’s Association International Conference
◇開催地◇
　Amsterdam, Netherland

◇開催期間◇
2023年7月14日 ～ 2023年7月20日

◇発表題目◇
Intergenerational Social Mobility, Brain Structure and Cognitive Trajectories: Findings from the Whitehall II Study

Figure 1. Upward mobility preserved larger gray matter volume (left) and cortical thickness (right) than downward mobility in later life. Color bar suggests logP value of ANCOVA (FDR.corr) tests.

◇発表内容◇
Intergenerational social mobility, i.e. moving up or down from one's original social position, not only indicates social equality and economic growth in a society, but also underlines health risk in old age. In this presentation, we explored the influence of social mobility, defined by occupational changes from the father, on the structural brain with longitudinal cognitive changes. 776 participants aged 60+ from the Whitehall II imaging sub-study (UK) were included. We firstly detected the brain map (Fig 1 gray matter volume and thickness) on regions related to different membership of social mobility. Then secondly, we imported the regions surpass multiple comparison correction into longitudinal growth curve models which aim to identify trajectories of three cognitive domains (global cognition, crystalized cognition and fluid intelligence) over 20 years. From the examination, we observed lower intercept of trajectory of fluid intelligence due to downward mobility. We additionally discussed possible societal solutions to address the transmitted inequalities in cognitive well-being as we age, that are: security on later life income and household, management on diabetes and hypertension.

◇今回の発表によって得られた成果及び問題点◇
Present study is the continuing project from last year on influence of socioeconomic disadvantages and cognitive well-being (DOI: 10.1093/geroni/igac059.2909), based on the idea that since socioeconomic disadvantage can begin before birth and accumulate throughout life, thus identifying resources to compensate for the accumulating health risk is crucial step for interrupting the transmission of disadvantages. The data were obtained from the UK dementia portal, motivated from same interest, I had the fortune to meet a staff scientist from UK dementia center and we discussed the results with future analyzing plan. The main limitation of present cohort is selection bias due to the average good level of socioeconomic status in the UK. Thus, the next step is to obtain behavioral data from 'worse off' populations-- marginalized groups in local communities such as informal workers, immigrants, and ethnic minorities, encompassed by cross-validation across different country sites, particularly from low-income countries.

◇今後の研究目標及び課題◇
During the conference, I met the researchers from Brazil and China who organized the local imaging cohort focusing on dementia prevention, and we positively discussed the chance to harmonize data resources and to initiate study on identifying ‘worse off ’ lifestyle risk of dementia in the same picture.